Diclocymet

Diclocymet

SCHEMBL2486533

CC(NC(=O)C(C#N)C(C)(C)C)c1ccc(Cl)cc1Cl.CC(Oc1ccc(Cl)cc1Cl)C(=O)NC(C)(C#N)C(C)C

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.44
LMNA P02545 4/20 0.43
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
ALDH1A1 P00352 3/20 0.42
KDM4E B2RXH2 2/20 0.42
GAA P10253 2/20 0.42
L3MBTL1 Q9Y468 3/20 0.41
HTT P42858 2/20 0.41
HPGD P15428 3/20 0.41
PKM P14618 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4620434 0.86 SMN1; SMN2 (0.57) SMN1; SMN2LMNATSHRMAPK1ALDH1A1
SCHEMBL4620213 0.86 SMN1; SMN2 (0.57) SMN1; SMN2LMNATSHRMAPK1ALDH1A1
SCHEMBL21094 0.86 SMN1; SMN2 (0.57) SMN1; SMN2LMNATSHRMAPK1ALDH1A1
SCHEMBL4620431 0.86 SMN1; SMN2 (0.57) SMN1; SMN2LMNATSHRMAPK1ALDH1A1
SCHEMBL4620207 0.86 SMN1; SMN2 (0.57) SMN1; SMN2LMNATSHRMAPK1ALDH1A1
Diclocymet SCHEMBL674273 0.83 MEN1 (0.50) LMNAL3MBTL1MEN1KMT2A
Diclocymet SCHEMBL4165786 0.83 MEN1 (0.50) LMNAL3MBTL1MEN1KMT2A
Diclocymet SCHEMBL42437 0.83 MEN1 (0.50) LMNAL3MBTL1MEN1KMT2A
Diclocymet SCHEMBL674274 0.83 MEN1 (0.50) LMNAL3MBTL1MEN1KMT2A
Diclocymet SCHEMBL8921616 0.83 MEN1 (0.50) LMNAL3MBTL1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110263608-A1 16-KETO ASPERGILLIMIDES AND HARMFUL ORGANISM CONTROL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT MEIJI SEIKA PHARMA CO., LTD. (JP) 2011-10-27 US disclosed
EP-2377398-A1 16-KETOASPERGILLIMIDE AND PEST EXTERMINATING AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT Meiji Seika Pharma Co., Ltd. (JP) 2011-10-19 EP disclosed
US-20090082389-A1 PESTICIDAL SUBSTITUTED PIPERIDINES MERIAL LIMITED 2009-03-26 US disclosed
EP-1848274-A1 PESTICIDAL SUBSTITUTED PIPERIDINES Merial Ltd. (US) 2007-10-31 EP disclosed
WO-2006087162-A1 PESTICIDAL SUBSTITUTED PIPERIDINES MERIAL LTD. (US) 2006-08-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090082389-A1 PESTICIDAL SUBSTITUTED PIPERIDINES PIR, ACHE, PREP SMN1; SMN2 2225/4885LMNA 2818/4885TSHR 1299/4885
US-20110263608-A1 16-KETO ASPERGILLIMIDES AND HARMFUL ORGANISM CONTROL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT CYP51A1, AKR7A2, CYP2C18 SMN1; SMN2 3197/4885LMNA 4183/4885TSHR 4190/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.