Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1369731 | 0.84 | HSPA5 (0.39) | PTGS1PTGS2POLBL3MBTL1MAPT | |
| SCHEMBL1369734 | 0.82 | SLC1A5 (0.49) | KMT2AMEN1HTTPOLBTP53 | |
| SCHEMBL1367547 | 0.81 | AR (0.52) | ARTSHRKMT2AMEN1PKM | |
| SCHEMBL1369142 | 0.81 | KDR (0.47) | HTTLMNAMAPT | |
| SCHEMBL1367422 | 0.78 | MAPT (0.56) | ARTSHRKMT2AHPGDHTT | |
| SCHEMBL1366570 | 0.76 | PARP1 (0.38) | PTGS1PTGS2TSHR | |
| SCHEMBL1367124 | 0.75 | L3MBTL1 (0.38) | PTGS1PTGS2TSHRPOLBL3MBTL1 | |
| SCHEMBL8473051 | 0.72 | PTGS2 (0.64) | PTGS1PTGS2KMT2AHPGDHTT | |
| SCHEMBL7885098 | 0.72 | PTGS2 (0.64) | PTGS1PTGS2KMT2AHPGDHTT | |
| SCHEMBL362211 | 0.72 | PTGS2 (0.64) | PTGS1PTGS2KMT2AHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377851-A1 | ISOQUINOLINE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2011-10-19 | — | — | EP | disclosed |