Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31370719 | 0.81 | AKR1C3 (0.39) | NOTUMAKR1C3ESR2ESR1HDAC8 | |
| SCHEMBL17813373 | 0.81 | AKR1C3 (0.39) | NOTUMAKR1C3ESR2ESR1HDAC8 | |
| SCHEMBL13405609 | 0.79 | NR1H2 (0.47) | HTR2ADRD2ESR2ESR1HSD17B3 | |
| SCHEMBL13112853 | 0.79 | HTR5A (0.36) | ESR2ESR1DRD1DRD5HDAC8 | |
| SCHEMBL19700137 | 0.79 | KCNH2 (0.50) | HTR2AHTR2BNOTUMDRD2ESR2 | |
| SCHEMBL13405606 | 0.77 | NOTUM (0.46) | HTR2AHTR2CHTR2BNOTUMACACB | |
| SCHEMBL21030558 | 0.77 | NPSR1 (0.36) | HTR2AHTR2CACACBESR2HDAC8 | |
| SCHEMBL6883015 | 0.77 | MAOA (0.59) | HTR2AHTR2CHTR2BDRD2DRD1 | |
| SCHEMBL861951 | 0.76 | MAOA (0.57) | NOTUMDRD2DRD1DRD5DRD3 | |
| SCHEMBL10153077 | 0.76 | HDAC6 (0.35) | HTR2AHTR2CDRD2ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230008433-A1 | Inhibitors of SARM1 | DISARM THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230008433-A1 | Inhibitors of SARM1 | SARM1, SMN1; SMN2, SARNP | HTR2A 3863/4885HTR2C 4400/4885HTR2B 4250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.