Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867288 | 0.88 | KDM4E (0.37) | RAB9ANPC1KDM4EALDH1A1RORC | |
| SCHEMBL24867244 | 0.86 | RAB9A (0.44) | RAB9ANPC1KDM4EALDH1A1RORC | |
| SCHEMBL24867269 | 0.83 | HDAC3 (0.43) | RAB9ANPC1KDM4EALDH1A1RORC | |
| SCHEMBL24867268 | 0.82 | CHEK1 (0.49) | RAB9ARORCCSNK2A1MAPK1 | |
| SCHEMBL24867287 | 0.82 | ACACB (0.39) | KDM4ERORCCCNA2CDK2CDK5 | |
| SCHEMBL24867240 | 0.81 | BRAF (0.42) | RAB9ACSNK2A1MAPK1MEN1KMT2A | |
| SCHEMBL24867238 | 0.79 | PANK3 (0.38) | — | |
| SCHEMBL24867254 | 0.78 | CSNK2A1 (0.40) | RAB9ARORCNTRK1CSNK2A1SMN1; SMN2 | |
| SCHEMBL24867276 | 0.78 | RAB9A (0.46) | RAB9AALDH1A1FLT3MAPK1 | |
| SCHEMBL30130179 | 0.77 | RAB9A (0.49) | RAB9ANPC1CDK2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |