Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867287 | 0.88 | ACACB (0.39) | KDM4EPOLBSMN1; SMN2CCNA2CDK2 | |
| SCHEMBL24867238 | 0.88 | PANK3 (0.38) | SYK | |
| SCHEMBL24867262 | 0.88 | RAB9A (0.44) | KDM4EPOLBSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL24867269 | 0.87 | HDAC3 (0.43) | KDM4ESMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL24867268 | 0.83 | CHEK1 (0.49) | SYKRAB9ACSNK2A1MAPK1RORC | |
| SCHEMBL24867240 | 0.82 | BRAF (0.42) | RAB9ACSNK2A1MAPK1 | |
| SCHEMBL30130213 | 0.81 | SYK (0.40) | SYKRAB9AMAPK1 | |
| SCHEMBL30130219 | 0.81 | SYK (0.40) | SYKRAB9AMAPK1 | |
| SCHEMBL24867276 | 0.80 | RAB9A (0.46) | SYKHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24867254 | 0.80 | CSNK2A1 (0.40) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |