Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31424918 | 0.84 | SMN1; SMN2 (0.48) | KMT2ATSHRHTTALDH1A1HPGD | |
| SCHEMBL26444538 | 0.84 | GAA (0.50) | KMT2ATSHRHTTBRD4ALDH1A1 | |
| SCHEMBL959908 | 0.84 | CTSD (0.50) | KMT2ATSHRHTTALDH1A1HPGD | |
| SCHEMBL2486331 | 0.84 | TSHR (0.58) | L3MBTL1KMT2ATSHRHTTBRD4 | |
| SCHEMBL31483721 | 0.81 | HTT (0.64) | L3MBTL1KMT2ATSHRHTTBRD4 | |
| SCHEMBL26417076 | 0.81 | HTT (0.64) | L3MBTL1KMT2ATSHRHTTBRD4 | |
| SCHEMBL10708923 | 0.80 | TP53 (0.41) | KMT2ATSHRHTTALDH1A1HPGD | |
| SCHEMBL20621120 | 0.80 | MEN1 (0.51) | L3MBTL1KMT2AHTTALDH1A1HPGD | |
| SCHEMBL166160 | 0.80 | TP53 (0.61) | L3MBTL1KMT2ATSHRHTTALDH1A1 | |
| SCHEMBL7223362 | 0.79 | KMT2A (0.44) | L3MBTL1KMT2ATSHRHTTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365809-A1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD Pharmaceuticals, Inc (US) | 2011-09-21 | — | — | EP | disclosed |
| WO-2010056311-A1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |