Sugi Predict

Sugi Predict / Compounds / SCHEMBL24868336

SCHEMBL24868336

SCHEMBL24868336

N#C[C@]1(O)C[C@@H](C(=O)O)C1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2C19 P33261 2/20 0.50
▸ APLNR P35414 1/20 0.46
▸ ALDH1A1 P00352 2/20 0.43
▸ CYP1A2 P05177 2/20 0.43
▸ ALOX15 P16050 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ GRM2 Q14416 2/20 0.33
▸ GRM3 Q14832 2/20 0.33
▸ GRM4 Q14833 2/20 0.33
▸ TSHR P16473 2/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ GRM8 O00222 1/20 0.33
▸ GRM6 O15303 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ GRM5 P41594 1/20 0.33
▸ MTOR P42345 1/20 0.33
▸ GRM1 Q13255 1/20 0.33
▸ PLCB1 Q9NQ66 1/20 0.33
▸ SLC6A4 P31645 1/20 0.32
▸ PDE4A P27815 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15193303 0.78 CYP2C19 (0.52) CYP2C19APLNRALDH1A1CYP1A2ALOX15
SCHEMBL24868406 0.74 CYP2C19 (0.48) CYP2C19APLNRALDH1A1CYP1A2ALOX15
SCHEMBL25252326 0.71 ALDH1A1 (0.33) ALDH1A1
SCHEMBL1507147 0.71 — —
SCHEMBL24867750 0.70 APLNR (0.45) CYP2C19APLNRALDH1A1CYP1A2ALOX15
SCHEMBL24868009 0.70 APLNR (0.45) CYP2C19APLNRALDH1A1CYP1A2ALOX15
SCHEMBL24807965 0.70 APLNR (0.45) CYP2C19APLNRALDH1A1CYP1A2ALOX15
SCHEMBL8512675 0.69 GRIN2B (0.33) ALDH1A1GRM5
SCHEMBL8512668 0.69 GRIN2B (0.33) ALDH1A1GRM5
SCHEMBL8512673 0.69 GRIN2B (0.33) ALDH1A1GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11912686-B2 LPA receptor antagonists and uses thereof GILEAD SCIENCES, INC. (US) 2024-02-27 — — US disclosed
US-11912686-B2 LPA receptor antagonists and uses thereof GILEAD SCIENCES, INC. (US) 2024-02-27 — — US disclosed
US-20230212151-A1 LPA RECEPTOR ANTAGONISTS AND USES THEREOF GILEAD SCIENCES, INC. 2023-07-06 — — US disclosed
US-20230212151-A1 LPA RECEPTOR ANTAGONISTS AND USES THEREOF GILEAD SCIENCES, INC. 2023-07-06 — — US disclosed
US-11584738-B2 LPA receptor antagonists and uses thereof GILEAD SCIENCES, INC. (US) 2023-02-21 — — US disclosed
US-20230012262-A1 LPA RECEPTOR ANTAGONISTS AND USES THEREOF GILEAD SCIENCES, INC. 2023-01-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11584738-B2 LPA receptor antagonists and uses thereof LPAR1, LPAR2, LPAR4 CYP2C19 4398/4885APLNR 103/4885ALDH1A1 1726/4885
US-20230212151-A1 LPA RECEPTOR ANTAGONISTS AND USES THEREOF LPAR1, LPAR2, LPAR4 CYP2C19 4398/4885APLNR 103/4885ALDH1A1 1726/4885
US-20230012262-A1 LPA RECEPTOR ANTAGONISTS AND USES THEREOF LPAR1, LPAR2, LPAR4 CYP2C19 4398/4885APLNR 103/4885ALDH1A1 1726/4885
US-11912686-B2 LPA receptor antagonists and uses thereof LPAR1, LPAR2, LPAR4 CYP2C19 4398/4885APLNR 103/4885ALDH1A1 1726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.