Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22984901 | 0.89 | LMNA (0.39) | PDE2ALMNAP2RX7PTGS2NOTUM | |
| SCHEMBL12303919 | 0.88 | PDE2A (0.42) | PDE2ALMNAP2RX7PTGS2NOTUM | |
| SCHEMBL23625165 | 0.87 | NOTUM (0.40) | PDE2AP2RX7NOTUMGABRA1GABRB1 | |
| SCHEMBL25787670 | 0.84 | PDE2A (0.40) | PDE2ALMNAP2RX7PTGS2NOTUM | |
| SCHEMBL24985319 | 0.80 | PDE2A (0.40) | PDE2ALMNAP2RX7PTGS2NOTUM | |
| SCHEMBL24165388 | 0.80 | NOTUM (0.39) | PDE2AP2RX7NOTUMGABRA1GABRB1 | |
| SCHEMBL11862411 | 0.79 | LMNA (0.52) | PDE2ALMNAPTGS2GABRA1GABRB1 | |
| SCHEMBL16736892 | 0.79 | LMNA (0.47) | PDE2ALMNAP2RX7PTGS2GABRA1 | |
| SCHEMBL24986401 | 0.79 | PDE2A (0.39) | PDE2ALMNAP2RX7PTGS2GABRA1 | |
| SCHEMBL18262832 | 0.75 | LMNA (0.42) | LMNANOTUMGABRA1GABRB1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023279986-A1 | SIX-MEMBERED ARYL OR HETEROARYL AMIDES, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2023-01-12 | — | — | WO | disclosed |