Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24868586 | 0.89 | PDE2A (0.42) | LMNAPDE2AP2RX7NOTUMAKR1C3 | |
| SCHEMBL23625165 | 0.84 | NOTUM (0.40) | PDE2AP2RX7NOTUMGABRA1GABRB1 | |
| SCHEMBL24165388 | 0.81 | NOTUM (0.39) | PDE2AP2RX7NOTUMGABRA1GABRB1 | |
| SCHEMBL11604200 | 0.80 | P2RX7 (0.32) | PDE2AP2RX7NOTUMAKR1C3AKR1C2 | |
| SCHEMBL20690300 | 0.80 | LMNA (0.41) | LMNAGABRA1GABRB1KDM4E | |
| SCHEMBL24985319 | 0.78 | PDE2A (0.40) | LMNAPDE2AP2RX7NOTUMAKR1C3 | |
| SCHEMBL12303919 | 0.77 | PDE2A (0.42) | LMNAPDE2AP2RX7NOTUMAKR1C3 | |
| SCHEMBL24986401 | 0.76 | PDE2A (0.39) | LMNAPDE2AP2RX7GABRA1GABRB1 | |
| SCHEMBL24946314 | 0.76 | LMNA (0.56) | LMNAPDE2AP2RX7GABRA1GABRB1 | |
| SCHEMBL16736892 | 0.76 | LMNA (0.47) | LMNAPDE2AP2RX7AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919850-B2 | Covalent inhibitors of KRas G12C | ARAXES PHARMA LLC (US) | 2021-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919850-B2 | Covalent inhibitors of KRas G12C | KRAS, NRAS, HRAS | LMNA 3439/4885PDE2A 4096/4885P2RX7 4810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.