Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.48 |
| ▸ | INSR | P06213 | 7/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphine SCHEMBL25950554 | 0.79 | ALK (0.60) | ALKINSRMAP4K1 | |
| Phosphine SCHEMBL25950543 | 0.75 | ALK (0.61) | ALKINSRMAP4K1EGFRMET | |
| Phosphine SCHEMBL24869966 | 0.73 | MAP4K1 (0.52) | ALKINSRMAP4K1MET | |
| SCHEMBL30875684 | 0.70 | ALK (0.61) | ALKINSRMAP4K1MET | |
| SCHEMBL20231589 | 0.68 | ALK (0.71) | ALKINSRMAP4K1MET | |
| SCHEMBL29805906 | 0.66 | MAP4K1 (0.77) | ALKINSRMAP4K1 | |
| SCHEMBL20214436 | 0.66 | MAP4K1 (0.77) | ALKINSRMAP4K1 | |
| SCHEMBL20214556 | 0.66 | MAP4K1 (0.77) | ALKINSRMAP4K1 | |
| SCHEMBL25337779 | 0.66 | MAP4K1 (0.62) | ALKINSRMAP4K1 | |
| SCHEMBL30183975 | 0.66 | MAP4K1 (0.62) | ALKINSRMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023281417-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALTY S.A. (CH) | 2023-01-12 | — | — | WO | disclosed |