Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494389 | 0.81 | HDAC6 (0.34) | HDAC6HDAC1HDAC2CA1CA2 | |
| SCHEMBL16076753 | 0.81 | CA1 (0.32) | MEN1GAAKMT2AHDAC6HDAC1 | |
| SCHEMBL30739107 | 0.81 | CA1 (0.32) | MEN1GAAKMT2AHDAC6HDAC1 | |
| SCHEMBL14450702 | 0.81 | CA1 (0.32) | MEN1GAAKMT2AHDAC6HDAC1 | |
| SCHEMBL29463474 | 0.79 | MEN1 (0.34) | MEN1GAAKMT2AHDAC6HDAC1 | |
| SCHEMBL28941238 | 0.79 | MEN1 (0.34) | MEN1GAAKMT2AHDAC6HDAC1 | |
| SCHEMBL2499624 | 0.79 | KMT2A (0.34) | MEN1GAAKMT2AHDAC6HDAC1 | |
| SCHEMBL11106058 | 0.79 | MEN1 (0.34) | MEN1GAAKMT2AHDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL14966370 | 0.79 | HDAC6 (0.33) | HDAC6HDAC1HDAC2CA1CA2 | |
| SCHEMBL342692 | 0.78 | AAK1 (0.33) | MEN1GAAKMT2AHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102932-B2 | Orthogonal translation components for the in vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-08-11 | — | — | US | disclosed |
| US-20130244245-A1 | Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-09-19 | — | — | US | disclosed |
| US-8216804-B2 | pairs of orthogonal-tRNAs (O-tRNAs) and orthogonal aminoacyl-tRNA synthetases (O RSs) that do not interact with the host cell translation machinery | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-07-10 | — | — | US | disclosed |
| EP-2383340-A2 | Orthogonal translation components for the in vivo incorporation of unnatural amino acids | The Scripps Research Institute (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-2380982-A1 | Orthogonal translation components for the in vivo incorporation of unnatural amino acids | The Scripps Research Institute (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20080233611-A1 | Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-25 | — | — | US | disclosed |
| EP-1807515-A4 | ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS | SCRIPPS RESEARCH INST (US) | 2008-06-18 | — | — | EP | disclosed |
| EP-1807515-A2 | ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS | The Scripps Research Institute (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006110182-A2 | ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-10-19 | — | — | WO | disclosed |
| EP-0304087-B1 | Quinolone and naphthyridine antibacterial agents containing an alpha-amino acid in the side chain of the 7-substituent | WARNER LAMBERT CO (US) | 1994-03-30 | — | — | EP | disclosed |
| US-4851418-A | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent | WARNER-LAMBERT COMPANY (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0304087-A2 | Quinolone and naphthyridine antibacterial agents containing an alpha-amino acid in the side chain of the 7-substituent | WARNER-LAMBERT COMPANY (US) | 1989-02-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080233611-A1 | Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids | AARS1, NSUN3, OSGEP | MEN1 3644/4885GAA 1763/4885KMT2A 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.