Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLTP | P55058 | 6/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488142 | 1.00 | PLTP (0.46) | PLTPRORCCNR2TRPV4CNR1 | |
| SCHEMBL2318053 | 1.00 | PLTP (0.46) | PLTPRORCCNR2TRPV4CNR1 | |
| SCHEMBL2313309 | 0.98 | PLTP (0.46) | PLTPRORCCNR2TRPV4HCRTR1 | |
| SCHEMBL2486886 | 0.98 | PLTP (0.46) | PLTPRORCCNR2TRPV4HCRTR1 | |
| SCHEMBL2489833 | 0.98 | PLTP (0.46) | PLTPRORCCNR2TRPV4HCRTR1 | |
| SCHEMBL2318323 | 0.86 | RORC (0.42) | PLTPRORCDGAT1ALDH1A1ADORA2A | |
| SCHEMBL2485500 | 0.86 | RORC (0.42) | PLTPRORCDGAT1ALDH1A1ADORA2A | |
| SCHEMBL2313536 | 0.85 | RORC (0.42) | PLTPRORCDGAT1ALDH1A1ADORA2A | |
| SCHEMBL2487013 | 0.85 | RORC (0.42) | PLTPRORCDGAT1ALDH1A1ADORA2A | |
| SCHEMBL2314437 | 0.84 | RORC (0.45) | PLTPRORCCNR2TRPV4DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |