Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC2 | Q13490 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14832834 | 1.00 | BIRC2 (0.45) | BIRC2ALDH1A1TP53HRH4MAPT | |
| SCHEMBL14860503 | 1.00 | BIRC2 (0.45) | BIRC2ALDH1A1TP53HRH4MAPT | |
| Hydrochloric Acid SCHEMBL21995972 | 0.98 | BIRC2 (0.44) | BIRC2ALDH1A1TP53HRH4MAPT | |
| Hydrochloric Acid SCHEMBL21995974 | 0.98 | BIRC2 (0.44) | BIRC2ALDH1A1TP53HRH4MAPT | |
| SCHEMBL1992770 | 0.83 | BIRC2 (0.47) | BIRC2ALDH1A1HRH4MAPTTPSAB1 | |
| SCHEMBL1992768 | 0.83 | BIRC2 (0.47) | BIRC2ALDH1A1HRH4MAPTTPSAB1 | |
| SCHEMBL2904241 | 0.81 | TPSAB1 (0.49) | ALDH1A1TP53MAPTGAATPSAB1 | |
| SCHEMBL2904236 | 0.81 | TPSAB1 (0.49) | ALDH1A1TP53MAPTGAATPSAB1 | |
| Hydrochloric Acid SCHEMBL21752648 | 0.80 | TPSAB1 (0.47) | ALDH1A1TP53MAPTTPSAB1TPSD1 | |
| SCHEMBL29190317 | 0.80 | TPSAB1 (0.51) | ALDH1A1TP53MAPTGAATPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230008022-A1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230008022-A1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | IDO1, IDO2, KYNU | BIRC2 946/4885ALDH1A1 328/4885TP53 2133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.