Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487858 | 0.87 | CHRM1 (0.52) | CNR2GRM2AOC3HDAC6CHRM1 | |
| SCHEMBL2488335 | 0.81 | CHRM1 (0.51) | CNR2GRM2AOC3HDAC6CHRM1 | |
| SCHEMBL2489376 | 0.79 | CHRM1 (0.52) | CHRM1BRD4ALDH1A1 | |
| SCHEMBL2489733 | 0.75 | CHRM1 (0.57) | CNR2CHRM1 | |
| SCHEMBL2488339 | 0.73 | CHRM1 (0.53) | CNR2CHRM1 | |
| SCHEMBL2488155 | 0.73 | CHRM1 (0.53) | CNR2CHRM1 | |
| SCHEMBL12206892 | 0.72 | CHRM1 (0.39) | CNR2GRM2AOC3CHRM1 | |
| SCHEMBL2491318 | 0.72 | CHRM1 (0.40) | CNR2CHRM1MAPT | |
| SCHEMBL2488333 | 0.72 | CHRM1 (0.66) | CNR2AOC3CHRM1NPC1RAB9A | |
| SCHEMBL2489439 | 0.71 | CHRM1 (0.51) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |