Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.52 |
| ▸ | TOP1 | P11387 | 4/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490230 | 0.89 | CHRM1 (0.68) | CHRM1TOP1 | |
| SCHEMBL2490909 | 0.87 | CHRM1 (0.50) | CHRM1TOP1CDK9MAPK8DRD2 | |
| SCHEMBL2490145 | 0.86 | CHRM1 (0.59) | CHRM1TOP1 | |
| SCHEMBL2487941 | 0.85 | CHRM1 (0.58) | CHRM1TOP1 | |
| SCHEMBL2488388 | 0.83 | CHRM1 (0.56) | CHRM1TOP1 | |
| SCHEMBL2489039 | 0.83 | CHRM1 (0.74) | CHRM1TOP1 | |
| SCHEMBL2488124 | 0.82 | CHRM1 (0.55) | CHRM1TOP1 | |
| SCHEMBL2485661 | 0.82 | CHRM1 (0.61) | CHRM1TOP1 | |
| SCHEMBL2488155 | 0.81 | CHRM1 (0.53) | CHRM1TOP1DRD3 | |
| SCHEMBL2488339 | 0.81 | CHRM1 (0.53) | CHRM1TOP1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |