Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.74 |
| ▸ | TOP1 | P11387 | 9/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234399 | 0.93 | CHRM1 (0.63) | CHRM1TP53MAPTLMNACNR2 | |
| SCHEMBL2492203 | 0.91 | CHRM1 (0.61) | CHRM1TOP1LMNA | |
| SCHEMBL2485661 | 0.90 | CHRM1 (0.61) | CHRM1TOP1 | |
| SCHEMBL2490145 | 0.89 | CHRM1 (0.59) | CHRM1TOP1TP53MAPT | |
| SCHEMBL2487941 | 0.88 | CHRM1 (0.58) | CHRM1TOP1TP53MAPT | |
| SCHEMBL2488682 | 0.87 | CHRM1 (0.57) | CHRM1TOP1TP53MAPT | |
| SCHEMBL2492079 | 0.87 | CHRM1 (0.57) | CHRM1TOP1MAPT | |
| SCHEMBL3234237 | 0.87 | CHRM1 (0.56) | CHRM1TP53MAPT | |
| SCHEMBL3232234 | 0.87 | CHRM1 (0.56) | CHRM1TP53LMNA | |
| SCHEMBL3234589 | 0.87 | CHRM1 (0.55) | CHRM1TP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |