Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.43 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1369152 | 0.89 | PTGDR2 (0.51) | MAPTGAATP53POLBTHRB | |
| SCHEMBL2485943 | 0.81 | SLC1A5 (0.44) | MAPTGAATP53POLBTHRB | |
| SCHEMBL13264273 | 0.80 | SLC1A5 (0.44) | MAPTSMN1; SMN2CARM1PRMT1SLC1A5 | |
| SCHEMBL1369734 | 0.80 | SLC1A5 (0.49) | MAPTGAATP53POLBTHRB | |
| SCHEMBL1367426 | 0.75 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2PTGDR2NPC1RAB9A | |
| SCHEMBL31757763 | 0.73 | L3MBTL1 (0.56) | MAPTGAATP53THRBKMT2A | |
| SCHEMBL2988197 | 0.73 | L3MBTL1 (0.56) | MAPTGAATP53THRBKMT2A | |
| SCHEMBL2487974 | 0.73 | SLC1A5 (0.42) | MAPTGAATP53POLBTHRB | |
| SCHEMBL2485285 | 0.73 | PTGDR2 (0.65) | PTGDR2 | |
| SCHEMBL14859529 | 0.72 | DPP4 (0.42) | GAASMN1; SMN2ALDH1A1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377851-A1 | ISOQUINOLINE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2011-10-19 | — | — | EP | disclosed |