Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30112339 | 1.00 | DDB1 (0.50) | DDB1CRBNHRH3ACACBCYP11B2 | |
| SCHEMBL31583894 | 0.90 | DDB1 (0.54) | DDB1CRBNHRH3 | |
| SCHEMBL25035460 | 0.86 | DDB1 (0.52) | DDB1CRBNACACBCYP11B2 | |
| SCHEMBL25823252 | 0.85 | DDB1 (0.59) | DDB1CRBNHRH3CYP11B2PARP1 | |
| SCHEMBL31470588 | 0.83 | CRBN (0.42) | DDB1CRBNHRH3 | |
| SCHEMBL38662683 | 0.83 | CRBN (0.42) | DDB1CRBNHRH3 | |
| SCHEMBL30511797 | 0.81 | DDB1 (0.49) | DDB1CRBNHRH3ACACBCYP11B2 | |
| SCHEMBL24880609 | 0.81 | POLB (0.36) | DDB1CRBN | |
| SCHEMBL29197732 | 0.81 | CRBN (0.43) | DDB1CRBNACACB | |
| SCHEMBL29197791 | 0.81 | CRBN (0.41) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940414-A | Compounds for targeting IRAK4 protein degradation | 渤健马萨诸塞州股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| WO-2023283610-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |