Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488205 | 0.89 | MAPT (0.53) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL2490128 | 0.82 | MAPT (0.61) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL2490357 | 0.78 | MAPT (0.56) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL2490934 | 0.78 | MAPT (0.56) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL2489392 | 0.76 | MAPT (0.54) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL2486765 | 0.76 | MAPT (0.56) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL2486759 | 0.76 | MAPT (0.56) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL2491071 | 0.73 | MAPT (0.52) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL10696897 | 0.73 | L3MBTL1 (0.51) | MAPTRAB9AGAAALDH1A1LMNA | |
| SCHEMBL2492671 | 0.70 | MAPT (0.46) | MAPTRAB9AGAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756112-B1 | PYRROLOBENZIMIDAZOLONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | BOEHRINGER INGELHEIM INT (DE) | 2011-10-26 | — | — | EP | disclosed |