Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643004 | 0.83 | ALDH1A1 (0.48) | L3MBTL1ALDH1A1TDP1MCL1LMNA | |
| SCHEMBL2489848 | 0.81 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1MCL1LMNAPOLB | |
| SCHEMBL644139 | 0.80 | ALDH1A1 (0.47) | L3MBTL1ALDH1A1TDP1LMNAPOLB | |
| SCHEMBL8118932 | 0.79 | KMT2A (0.54) | L3MBTL1LMNAPOLBMEN1KMT2A | |
| SCHEMBL5128567 | 0.78 | BDKRB1 (0.45) | L3MBTL1ALDH1A1TDP1LMNABDKRB1 | |
| SCHEMBL5206428 | 0.76 | PPARG (0.41) | L3MBTL1ALDH1A1TDP1LMNANPSR1 | |
| SCHEMBL5210764 | 0.76 | PPARD (0.48) | — | |
| SCHEMBL927220 | 0.74 | BDKRB1 (0.51) | BDKRB1MEN1KMT2A | |
| SCHEMBL493248 | 0.73 | PSEN1 (0.54) | BDKRB1 | |
| SCHEMBL4401630 | 0.72 | BDKRB1 (0.55) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |