SCHEMBL24891981

SCHEMBL24891981

N#Cc1c(Cl)nc(NI)c2c1CN(Cc1ccccc1)CC2

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.71
KDM4E B2RXH2 9/20 0.71
MAPT P10636 9/20 0.71
KMT2A Q03164 4/20 0.71
HPGD P15428 3/20 0.71
GLA P06280 2/20 0.71
GAA P10253 2/20 0.71
NPSR1 Q6W5P4 5/20 0.53
HIF1A Q16665 3/20 0.53
CASP1 P29466 3/20 0.53
CASP7 P55210 3/20 0.53
HSD17B10 Q99714 3/20 0.53
ALOX15 P16050 2/20 0.53
USP2 O75604 1/20 0.53
ESR1 P03372 1/20 0.53
RUNX1 Q01196 1/20 0.53
CBFB Q13951 1/20 0.53
TSHR P16473 1/20 0.52
ACHE P22303 6/20 0.51
LMNA P02545 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24891797 0.87 ALDH1A1 (0.69) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL24891791 0.86 ALDH1A1 (0.90) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL30183364 0.86 ALDH1A1 (0.90) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL15238668 0.83 ALDH1A1 (1.00) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL24892232 0.83 ALDH1A1 (0.62) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL24892268 0.83 ALDH1A1 (0.72) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL24892528 0.79 ALDH1A1 (0.66) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL25423358 0.78 ALDH1A1 (0.67) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL24892008 0.78 ALDH1A1 (0.55) ALDH1A1KDM4EMAPTKMT2AHPGD
SCHEMBL24892035 0.77 ALDH1A1 (0.63) ALDH1A1KDM4EMAPTKMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023285583-A1 5,6,7,8-TETRAHYDRO-2,6- AND 2,7-NAPHTHYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES RESPONSIVE TO CITRATE TRANSPORTER MODULATION ETERNYGEN UK LTD. (GB) 2023-01-19 WO disclosed