Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.72 |
| ▸ | MAPT | P10636 | 11/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | HPGD | P15428 | 3/20 | 0.72 |
| ▸ | GLA | P06280 | 2/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.62 |
| ▸ | CASP1 | P29466 | 3/20 | 0.62 |
| ▸ | CASP7 | P55210 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.62 |
| ▸ | CBFB | Q13951 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24891797 | 0.96 | ALDH1A1 (0.69) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL24892235 | 0.87 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL24892528 | 0.87 | ALDH1A1 (0.66) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL24892008 | 0.86 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL24892237 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL24892098 | 0.85 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL24892298 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL15238668 | 0.84 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL24892035 | 0.83 | ALDH1A1 (0.63) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| SCHEMBL24891981 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KDM4EMAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023285583-A1 | 5,6,7,8-TETRAHYDRO-2,6- AND 2,7-NAPHTHYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES RESPONSIVE TO CITRATE TRANSPORTER MODULATION | ETERNYGEN UK LTD. (GB) | 2023-01-19 | — | — | WO | disclosed |