Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.61 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.49 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490524 | 0.91 | CHRM1 (0.71) | CHRM1LMNATP53 | |
| SCHEMBL2485974 | 0.87 | CHRM1 (0.82) | CHRM1SLC5A1SLC5A2LMNASMN1; SMN2 | |
| SCHEMBL3239675 | 0.86 | CHRM1 (0.57) | CHRM1LMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL2487847 | 0.86 | CHRM1 (0.70) | CHRM1SLC5A1SLC5A2LMNASMN1; SMN2 | |
| SCHEMBL2489733 | 0.84 | CHRM1 (0.57) | CHRM1SLC5A1SLC5A2LMNATP53 | |
| SCHEMBL2492203 | 0.84 | CHRM1 (0.61) | CHRM1SLC5A1SLC5A2LMNASMN1; SMN2 | |
| SCHEMBL2491002 | 0.83 | CHRM1 (0.71) | CHRM1LMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL3237319 | 0.82 | CHRM1 (0.53) | CHRM1LMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL2487138 | 0.82 | CHRM1 (0.52) | CHRM1SLC5A1SLC5A2TP53 | |
| SCHEMBL3242044 | 0.81 | CHRM1 (0.49) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |