Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490511 | 0.91 | LMNA (0.59) | CHRM1LMNA | |
| SCHEMBL2487853 | 0.87 | CHRM1 (0.93) | CHRM1POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3237179 | 0.84 | LMNA (0.59) | CHRM1LMNA | |
| SCHEMBL3234156 | 0.84 | LMNA (0.62) | CHRM1LMNA | |
| SCHEMBL2489217 | 0.83 | CHRM1 (0.61) | CHRM1POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2492203 | 0.83 | CHRM1 (0.61) | CHRM1POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1549479 | 0.83 | CHRM1 (1.00) | CHRM1POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL31653939 | 0.83 | CHRM1 (1.00) | CHRM1POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3234258 | 0.83 | CHRM1 (0.55) | CHRM1POLBSMN1; SMN2LMNA | |
| SCHEMBL3236676 | 0.83 | CHRM1 (0.55) | CHRM1POLBSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |