Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.71 |
| ▸ | TOP1 | P11387 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239675 | 0.91 | CHRM1 (0.57) | CHRM1TP53LMNACYP1A2CYP2C9 | |
| SCHEMBL2489217 | 0.91 | CHRM1 (0.61) | CHRM1TP53LMNA | |
| SCHEMBL2489733 | 0.89 | CHRM1 (0.57) | CHRM1TOP1TP53SERPINE1LMNA | |
| SCHEMBL3237319 | 0.87 | CHRM1 (0.53) | CHRM1TP53LMNACYP1A2CYP2C9 | |
| SCHEMBL2486079 | 0.85 | CHRM1 (0.70) | CHRM1TOP1TP53SERPINE1 | |
| SCHEMBL2487138 | 0.85 | CHRM1 (0.52) | CHRM1TOP1TP53CNR2 | |
| SCHEMBL3242044 | 0.85 | CHRM1 (0.49) | CHRM1 | |
| SCHEMBL2487888 | 0.84 | CHRM1 (0.52) | CHRM1TP53 | |
| SCHEMBL2490523 | 0.83 | CHRM1 (1.00) | CHRM1TOP1LMNA | |
| SCHEMBL2490909 | 0.83 | CHRM1 (0.50) | CHRM1TOP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |