SCHEMBL24896282

SCHEMBL24896282

Cn1c(C(=O)NC(C)(C)C)cc2ccnc(Cl)c21

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 1/20 0.41
▸ CNR1 P21554 2/20 0.41
▸ CNR2 P34972 2/20 0.39
▸ POLB P06746 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ ANO1 Q5XXA6 9/20 0.37
▸ RIPK1 Q13546 1/20 0.37
▸ HPGDS O60760 1/20 0.36
▸ RXFP1 Q9HBX9 1/20 0.35
▸ NR1I2 O75469 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24896265 0.82 MAPT (0.46) TP53POLBMAPT
SCHEMBL20504453 0.80 MCL1 (0.45) MAPTRXFP1
SCHEMBL20504325 0.80 L3MBTL1 (0.47) MAPT
SCHEMBL24896281 0.79 PDE4B (0.50) CNR1POLB
SCHEMBL24896271 0.78 PHGDH (0.41) ANO1
SCHEMBL24896277 0.78 ANO1 (0.40) CNR1CNR2MAPTANO1RXFP1
SCHEMBL24896285 0.77 ANO1 (0.40) CNR2ANO1RXFP1
SCHEMBL24896288 0.77 KDM4E (0.50) CNR1CNR2POLB
SCHEMBL25002469 0.76 HDAC1 (0.36) TP53MAPTRXFP1
SCHEMBL24896350 0.76 GRM4 (0.41) CNR1CNR2ANO1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4370207-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS Nido Biosciences, Inc. (US) 2024-05-22 — — EP disclosed
US-20230039586-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2023-02-09 — — US disclosed
WO-2023287704-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. (US) 2023-01-19 — — WO disclosed
WO-2023287704-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. (US) 2023-01-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230039586-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 TP53 4119/4885CNR1 633/4885CNR2 997/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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