SCHEMBL24896285

SCHEMBL24896285

Cn1c(C(=O)NC2(C)CCC2)cc2ccnc(Cl)c21

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ ANO1 Q5XXA6 10/20 0.40
▸ PARG Q86W56 1/20 0.37
▸ ABL1 P00519 4/20 0.37
▸ PDE4A P27815 1/20 0.35
▸ PDE4B Q07343 1/20 0.35
▸ PDE4C Q08493 1/20 0.35
▸ PDE4D Q08499 1/20 0.35
▸ WDR5 P61964 1/20 0.33
▸ CNR2 P34972 1/20 0.32
▸ RXFP1 Q9HBX9 1/20 0.32
▸ ROCK2 O75116 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24896277 0.85 ANO1 (0.40) ANO1PARGCNR2RXFP1
SCHEMBL24896350 0.81 GRM4 (0.41) ANO1PDE4BCNR2RXFP1
SCHEMBL25002467 0.80 PDE4B (0.39) PDE4BCNR2
SCHEMBL24896278 0.80 CNR2 (0.40) CNR2
SCHEMBL24896265 0.79 MAPT (0.46) —
SCHEMBL24896281 0.79 PDE4B (0.50) PDE4B
SCHEMBL24896287 0.77 PDE4B (0.38) PDE4BCNR2
SCHEMBL24896288 0.77 KDM4E (0.50) PDE4BCNR2
SCHEMBL24896282 0.77 TP53 (0.41) ANO1CNR2RXFP1
SCHEMBL20504453 0.76 MCL1 (0.45) RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4370207-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS Nido Biosciences, Inc. (US) 2024-05-22 — — EP disclosed
US-20230039586-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2023-02-09 — — US disclosed
WO-2023287704-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. (US) 2023-01-19 — — WO disclosed
WO-2023287704-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. (US) 2023-01-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230039586-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 ANO1 2433/4885PARG 3751/4885ABL1 4632/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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