Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | PI4KA | P42356 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.56 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.56 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.50 |
| ▸ | PNP | P00491 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29354479 | 0.95 | YTHDC1 (0.69) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL20275396 | 0.95 | YTHDC1 (0.69) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL243515 | 0.95 | YTHDC1 (0.69) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL20275400 | 0.93 | YTHDC1 (0.72) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL244963 | 0.93 | YTHDC1 (0.72) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL29353722 | 0.93 | YTHDC1 (0.72) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL4148488 | 0.92 | TP53 (0.66) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL4151824 | 0.89 | YTHDC1 (0.66) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL179599 | 0.85 | YTHDC1 (0.59) | YTHDC1TP53CYP2C9NFKB1MAPK1 | |
| SCHEMBL17262848 | 0.83 | PI4KA (0.64) | YTHDC1TP53CYP2C9NFKB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139894-B1 | 9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7) MODULATORS | ASTRAZENECA AB (SE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2132209-A1 | 9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7 ) MODULATORS | AstraZeneca AB (SE) | 2009-12-16 | — | — | EP | disclosed |
| EP-2041135-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | Astra Zeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008114008-A1 | 9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7 ) MODULATORS | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008004948-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |