SCHEMBL2489821

SCHEMBL2489821

O=C(Nc1cccc(-c2ccc(Cl)cc2)n1)c1ccc(Oc2cc3c(cc2Cl)CCCO3)cc1

nearest known ligand 0.69

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 14/20 0.69
ADORA3 P0DMS8 1/20 0.45
RXFP1 Q9HBX9 1/20 0.42
PNLIP P16233 1/20 0.41
GRM5 P41594 2/20 0.40
NPC1 O15118 1/20 0.40
PKM P14618 1/20 0.40
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2489689 0.94 PTGDR2 (0.62) PTGDR2ADORA3NPC1RAB9A
SCHEMBL2490747 0.93 PTGDR2 (0.61) PTGDR2ADORA3GRM5
SCHEMBL2492752 0.89 PTGDR2 (0.56) PTGDR2
SCHEMBL2492651 0.89 PTGDR2 (0.56) PTGDR2ADORA3GRM5NPC1PKM
SCHEMBL2490235 0.87 PTGDR2 (0.53) PTGDR2
SCHEMBL2489986 0.86 PTGDR2 (0.53) PTGDR2NPC1RAB9A
SCHEMBL2487972 0.85 PTGDR2 (0.51) PTGDR2GRM5NPC1PKMRAB9A
SCHEMBL2487269 0.85 PTGDR2 (0.51) PTGDR2GRM5NPC1PKMRAB9A
SCHEMBL2489827 0.85 PTGDR2 (0.51) PTGDR2RXFP1NPC1RAB9A
SCHEMBL2487257 0.85 PTGDR2 (0.51) PTGDR2GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379535-A1 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES Array Biopharma Inc. (US) 2011-10-26 EP disclosed