Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16503921 | 0.82 | MTOR (0.42) | DYRK1APIM1DYRK2DYRK1BMTOR | |
| SCHEMBL12516813 | 0.80 | DYRK1A (0.51) | DYRK1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29637091 | 0.78 | DYRK1A (0.49) | DYRK1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7896922 | 0.78 | DYRK1A (0.49) | DYRK1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492639 | 0.78 | DYRK1A (0.49) | DYRK1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6915415 | 0.78 | DYRK1A (0.49) | DYRK1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11919644 | 0.75 | WNT3A (0.54) | DYRK1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11308138 | 0.75 | CYP1A1 (0.46) | CYP3A4CYP2D6CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL2516529 | 0.75 | DYRK1A (0.56) | DYRK1APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2489888 | 0.74 | ALDH1A1 (0.50) | DYRK1APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110313001-A1 | TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | FISCHER CHRISTIAN (US) | 2011-12-22 | — | — | US | disclosed |
| US-20110313001-A1 | TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | FISCHER CHRISTIAN (US) | 2011-12-22 | — | — | US | disclosed |
| EP-2379075-A1 | TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Corp. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010077582-A1 | TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME CORP. (US) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110313001-A1 | TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MAPT, BACE1, APP | DYRK1A 1171/4885PSEN1 5/4885PSEN2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.