Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.61 |
| ▸ | NQO2 | P16083 | 1/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1296715 | 0.90 | MET (0.76) | METNQO2 | |
| SCHEMBL2531744 | 0.90 | MET (0.62) | METNQO2CHEK2 | |
| SCHEMBL2455889 | 0.88 | MET (0.78) | METNQO2 | |
| SCHEMBL2535395 | 0.85 | MET (0.65) | METNQO2 | |
| SCHEMBL12216835 | 0.83 | MET (0.72) | METNQO2 | |
| SCHEMBL2455548 | 0.81 | MET (0.79) | METNQO2 | |
| SCHEMBL3084089 | 0.81 | MET (0.78) | METNQO2 | |
| SCHEMBL2455804 | 0.80 | MET (0.72) | METNQO2 | |
| SCHEMBL2480686 | 0.80 | MET (0.80) | METNQO2 | |
| SCHEMBL12106973 | 0.80 | MET (0.60) | METNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367815-A1 | PYRIDAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010072296-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-01 | — | — | WO | disclosed |