Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | FCER2 | P06734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25356314 | 0.88 | MDM4 (0.49) | MDM4TP53PTPN1MDM2 | |
| SCHEMBL31210307 | 0.88 | MDM4 (0.49) | MDM4TP53PTPN1MDM2 | |
| SCHEMBL30229488 | 0.88 | MDM4 (0.49) | MDM4TP53PTPN1MDM2 | |
| SCHEMBL25356318 | 0.88 | MDM4 (0.49) | MDM4TP53PTPN1MDM2 | |
| SCHEMBL24915788 | 0.86 | MDM4 (0.43) | MDM4TP53PTPN1MDM2 | |
| SCHEMBL29529376 | 0.86 | CTSB (0.46) | MDM4TP53CTSBCTSSCTSK | |
| SCHEMBL26509386 | 0.84 | ROCK2 (0.44) | MDM4TP53CTSBCTSSCTSK | |
| SCHEMBL26167007 | 0.84 | ROCK2 (0.44) | MDM4TP53CTSBCTSSCTSK | |
| SCHEMBL30229495 | 0.84 | ROCK2 (0.44) | MDM4TP53CTSBCTSSCTSK | |
| SCHEMBL26509307 | 0.84 | MDM2 (0.46) | MDM4TP53PTPN1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059472-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2023192873-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023102507-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-08 | — | — | WO | disclosed |
| WO-2023288213-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-19 | — | — | WO | disclosed |