Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30229631 | 1.00 | MDM4 (0.46) | MDM4TP53MDM2CTSSCTSK | |
| SCHEMBL24899402 | 1.00 | MDM4 (0.46) | MDM4TP53MDM2CTSSCTSK | |
| SCHEMBL29221368 | 0.88 | MDM4 (0.52) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL29221366 | 0.88 | MDM4 (0.52) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL24899359 | 0.85 | MDM4 (0.46) | MDM4TP53MDM2CTSSCTSK | |
| SCHEMBL24899358 | 0.85 | MDM4 (0.46) | MDM4TP53MDM2CTSSCTSK | |
| SCHEMBL30229501 | 0.85 | MDM4 (0.46) | MDM4TP53MDM2CTSSCTSK | |
| SCHEMBL24915228 | 0.84 | MDM4 (0.43) | MDM4TP53MDM2CTSSCTSK | |
| SCHEMBL24899401 | 0.82 | MDM2 (0.47) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL29529827 | 0.82 | MDM4 (0.44) | MDM4TP53MDM2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192873-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023288213-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-19 | — | — | WO | disclosed |