Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24915053 | 0.86 | MDM4 (0.43) | MDM4TP53SLC17A5MDM2PTPN1 | |
| SCHEMBL29221366 | 0.84 | MDM4 (0.52) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL29221368 | 0.84 | MDM4 (0.52) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL24899401 | 0.84 | MDM2 (0.47) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL24899402 | 0.84 | MDM4 (0.46) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL30229631 | 0.84 | MDM4 (0.46) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL24899400 | 0.84 | MDM4 (0.46) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL24915788 | 0.83 | MDM4 (0.43) | MDM4TP53SLC17A5MDM2PTPN1 | |
| SCHEMBL800112 | 0.77 | MDM4 (0.53) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL3725031 | 0.77 | MDM4 (0.53) | MDM4TP53SLC17A5MDM2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225661-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023102507-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-08 | — | — | WO | disclosed |
| WO-2023004240-A1 | MACROCYLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-26 | — | — | WO | disclosed |