Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 6/20 | 1.00 |
| ▸ | HSD11B2 | P80365 | 5/20 | 1.00 |
| ▸ | HSD11B1 | P28845 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.79 |
| ▸ | LMNA | P02545 | 5/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.79 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | TSHR | P16473 | 3/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.79 |
| ▸ | SHBG | P04278 | 3/20 | 0.79 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.79 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.79 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.79 |
| ▸ | THPO | P40225 | 2/20 | 0.79 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.79 |
| ▸ | BLM | P54132 | 1/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 11Beta-Hydroxyprogesterone SCHEMBL18927076 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL572275 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL14217113 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL985222 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL23131395 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL656895 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL19327159 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL13753022 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL4895684 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 | |
| 11Beta-Hydroxyprogesterone SCHEMBL14039977 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288123-A1 | METHODS AND INTERMEDIATES FOR THE PREPARATION OF 3.ALPHA.,7.ALPHA.,11.BETA.-TRIHYDROXY-6.ALPHA.-ETHYL-5.BETA.-CHOLAN-24-OIC ACID | INTERECEPT PHARMACEUTICALS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |