11Beta-Hydroxyprogesterone

11Beta-Hydroxyprogesterone

SCHEMBL656895

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 1.00
NR3C2 P08235 6/20 1.00
HSD11B2 P80365 5/20 1.00
HSD11B1 P28845 2/20 1.00
CYP3A4 P08684 7/20 0.79
LMNA P02545 5/20 0.79
HIF1A Q16665 5/20 0.79
CYP2C9 P11712 4/20 0.79
SERPINA6 P08185 4/20 0.79
MAPT P10636 3/20 0.79
TSHR P16473 3/20 0.79
MAPK1 P28482 3/20 0.79
SHBG P04278 3/20 0.79
SLC22A2 O15244 2/20 0.79
SLC22A1 O15245 2/20 0.79
SLC22A3 O75751 2/20 0.79
THPO P40225 2/20 0.79
SIGMAR1 Q99720 2/20 0.79
BLM P54132 1/20 0.79
NFKB1 P19838 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
11Beta-Hydroxyprogesterone SCHEMBL18927076 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL572275 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL14217113 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL985222 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL23131395 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL24900301 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL19327159 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL13753022 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL4895684 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL14039977 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250279209-A1 PROVISION OF A MEDICAL RISK ASSESSMENT FOR NONCLASSICAL 21-HYDROXYLASE DEFICIENCY UNIV SORBONNE (FR) 2025-09-04 US claimed
EP-4511660-A1 PROVISION OF A MEDICAL RISK ASSESSMENT FOR NONCLASSICAL 21-HYDROXYLASE DEFICIENCY SORBONNE UNIVERSITE (FR) 2025-02-26 EP claimed
CN-117805284-B Method for simultaneously detecting multiple precocious biomarkers 裕菁科技(上海)有限公司 2025-02-25 CN claimed
CN-118647367-A Novel injectable combination formulations 南爱克萨股份公司 2024-09-13 CN claimed
CN-118584010-A Primary aldosteronism steroid hormone model, preparation method and application thereof 上海交通大学医学院附属瑞金医院 2024-09-03 CN claimed
CN-117849228-A Biomarker for screening early sexual precocity and application thereof 裕菁科技(上海)有限公司 2024-04-09 CN claimed
CN-117805284-A Method for simultaneously detecting multiple precocious biomarkers 裕菁科技(上海)有限公司 2024-04-02 CN claimed
CN-117030904-B Method for measuring 144 steroid hormones in environmental sample by liquid chromatography-mass spectrometry 北京林业大学 2023-12-19 CN claimed
CN-117030904-A Method for measuring 144 steroid hormones in environmental sample by liquid chromatography-mass spectrometry 北京林业大学 2023-11-10 CN claimed
WO-2023203284-A1 PROVISION OF A MEDICAL RISK ASSESSMENT FOR NONCLASSICAL 21-HYDROXYLASE DEFICIENCY SORBONNE UNIVERSITE (FR) 2023-10-26 WO claimed
CN-116448923-A Methods and kits for extracting and detecting steroid hormones and catecholamine metabolites 中国医学科学院北京协和医院 2023-07-18 CN claimed
US-20210386712-A1 NEW USE OF ANGIOTENSIN II TYPE 2 RECEPTOR AGONIST VICORE PHARMA AB (SE) 2021-12-16 US claimed
US-20210299143-A1 USE OF ANTAGONISTS TO THE NUCLEAR STEROID RECEPTOR TO INHIBIT CORONAVIRUSES Spectral Analytics, Inc. (US) 2021-09-30 US claimed
US-10088490-B2 Assay for analytes using multiple receptors SIEMENS HEALTHCARE DIAGNOSTICS INC. (US) 2018-10-02 US claimed
US-20150376225-A1 NOVEL COMPOUNDS OF 11BETA-HYDROXY-STEROIDS FOR USE IN MITOCHONDRIA BIOGENESIS AND DISEASES ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION OR DEPLETION EPIRIUM BIO INC. 2015-12-31 US claimed
US-20090053294-A1 Anti Mineralocorticoid Therapy of Infection PRENDERGAST PATRICK T 2009-02-26 US claimed
EP-0141684-B1 HYDROCORTISONE-17-CARBOXYLIC-ACID ESTER 21-THIOCARBOXYLYC-ACID ESTERS, THEIR PREPARATION AND THEIR USE AS MEDICINES JOUVEINAL S.A. (FR) 1987-09-30 EP claimed
EP-0054390-B1 DEHALOGENATION OF STEROIDS THE UPJOHN COMPANY (US) 1984-07-25 EP claimed
EP-0054390-A1 Dehalogenation of steroids THE UPJOHN COMPANY (US) 1982-06-23 EP claimed
US-4325881-A Debromination THE UPJOHN COMPANY (US) 1982-04-20 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150376225-A1 NOVEL COMPOUNDS OF 11BETA-HYDROXY-STEROIDS FOR USE IN MITOCHONDRIA BIOGENESIS AND DISEASES ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION OR DEPLETION CYP27A1, CYP27B1, TFAM SMN1; SMN2 623/4885NR3C2 285/4885HSD11B2 152/4885
US-20090053294-A1 Anti Mineralocorticoid Therapy of Infection NR3C2, HSPB1, HSP90AB2P SMN1; SMN2 3817/4885NR3C2 1/4885HSD11B2 66/4885
US-20210299143-A1 USE OF ANTAGONISTS TO THE NUCLEAR STEROID RECEPTOR TO INHIBIT CORONAVIRUSES NCOA1, NCOA2, NCOA3 SMN1; SMN2 3109/4885NR3C2 9/4885HSD11B2 39/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.