11Beta-Hydroxyprogesterone

11Beta-Hydroxyprogesterone

SCHEMBL572275

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O)C[C@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 1.00
NR3C2 P08235 6/20 1.00
HSD11B2 P80365 5/20 1.00
HSD11B1 P28845 2/20 1.00
CYP3A4 P08684 7/20 0.79
LMNA P02545 5/20 0.79
HIF1A Q16665 5/20 0.79
CYP2C9 P11712 4/20 0.79
SERPINA6 P08185 4/20 0.79
MAPT P10636 3/20 0.79
TSHR P16473 3/20 0.79
MAPK1 P28482 3/20 0.79
SHBG P04278 3/20 0.79
SLC22A2 O15244 2/20 0.79
SLC22A1 O15245 2/20 0.79
SLC22A3 O75751 2/20 0.79
THPO P40225 2/20 0.79
SIGMAR1 Q99720 2/20 0.79
BLM P54132 1/20 0.79
NFKB1 P19838 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
11Beta-Hydroxyprogesterone SCHEMBL18927076 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL14217113 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL985222 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL23131395 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL656895 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL24900301 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL19327159 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL13753022 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL4895684 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4
11Beta-Hydroxyprogesterone SCHEMBL14039977 1.00 SMN1; SMN2 (1.00) SMN1; SMN2NR3C2HSD11B2HSD11B1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 208 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025059302-A1 COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATMENT AND MODULATION OF ACUTE AND CHRONIC SYMPTOMS OF MITOCHONDRIAL DISEASE AND DYSFUNCTION THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2025-03-20 WO claimed
US-20250017895-A1 FLAVANOID CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2025-01-16 US claimed
CN-114836387-B 11-alpha hydroxyprogesterone monoclonal antibody hybridoma cell strain and application thereof 江南大学 2023-08-04 CN claimed
WO-2023097328-A2 FLAVANOID CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2023-06-01 WO claimed
CN-115607510-A High-concentration oleanolic acid nanoemulsion composition and preparation method thereof 泉州达浔生物科技有限公司 2023-01-17 CN claimed
US-11207511-B2 Methods for treating baldness and promoting hair growth FOLLICA, INC. (US) 2021-12-28 US claimed
CN-109517020-A The synthetic method of Delta-9,11- hydroxyl progesterone 湖南原野医药有限公司 2019-03-26 CN claimed
US-20140079686-A1 Methods For Treating Baldness And Promoting Hair Growth FOLLICA, INC. 2014-03-20 US claimed
US-8470602-B2 Methods and systems for determining the presence or amount of delta 5 steroid compounds in a sample LABORATORY CORPORATION OF AMERICA HOLDINGS (US) 2013-06-25 US claimed
US-20120270327-A1 Methods and Systems for Determining the Presence or Amount of Delta 5 Steroid Compounds in a Sample LABORATORY CORPORATION OF AMERICA HOLDINGS (US) 2012-10-25 US claimed
EP-1473300-B1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PSORIASIS AND OTHER SKIN DISEASES LITAPHAR LAB S A (ES) 2008-11-26 EP claimed
EP-1613357-B1 GONADOTROPIN RELEASING HORMONE ANALOGUE CONJUGATES WITH STEROID HORMONES MEDICAL RES COUNCIL (GB) 2008-10-15 EP claimed
US-20060099643-A1 Method for determining the regulation of xenobiotic removal JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT LLC 2006-05-11 US claimed
US-20040225140-A1 Pharmaceutical composition for the treatment of psoriasis and other skin diseases FERNANDEZ PIDAL (ES) 2004-11-11 US claimed
EP-1473300-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PSORIASIS AND OTHER SKIN DISEASES Litaphar Laboratorios S.A. (ES) 2004-11-03 EP claimed
US-5968918-A Method for the prevention of coronary artery spasm KANDA IWAO (US) 1999-10-19 US claimed
US-4885289-A APPLYING ANTIANDROGEN TO SKIN GILLETTE COMPANY 1989-12-05 US claimed
EP-0141684-B1 HYDROCORTISONE-17-CARBOXYLIC-ACID ESTER 21-THIOCARBOXYLYC-ACID ESTERS, THEIR PREPARATION AND THEIR USE AS MEDICINES JOUVEINAL S.A. (FR) 1987-09-30 EP claimed
EP-0054390-B1 DEHALOGENATION OF STEROIDS THE UPJOHN COMPANY (US) 1984-07-25 EP claimed
US-4272508-A TREATMENT WITH 11-2-HYDROXYPROGESTERONE AND ESTERS THEREOF TAMM JURGEN 1981-06-09 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140079686-A1 Methods For Treating Baldness And Promoting Hair Growth AREG, FGF1, NGF SMN1; SMN2 4725/4885NR3C2 376/4885HSD11B2 266/4885
US-11207511-B2 Methods for treating baldness and promoting hair growth AREG, FGF1, NGF SMN1; SMN2 4725/4885NR3C2 376/4885HSD11B2 266/4885
US-20040225140-A1 Pharmaceutical composition for the treatment of psoriasis and other skin diseases HSD17B7, HSD17B1, CYP17A1 SMN1; SMN2 3856/4885NR3C2 27/4885HSD11B2 15/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.