Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.80 |
| ▸ | EGFR | P00533 | 16/20 | 0.76 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.76 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.76 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | JAK1 | P23458 | 1/20 | 0.65 |
| ▸ | TTK | P33981 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | TXK | P42681 | 1/20 | 0.65 |
| ▸ | BLK | P51451 | 1/20 | 0.65 |
| ▸ | BTK | Q06187 | 1/20 | 0.65 |
| ▸ | ITK | Q08881 | 1/20 | 0.65 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30221290 | 1.00 | JAK3 (0.80) | JAK3EGFRNUAK1NUAK2JAK2 | |
| SCHEMBL30221268 | 0.92 | EGFR (0.84) | JAK3EGFRALK | |
| SCHEMBL24900436 | 0.92 | EGFR (0.84) | JAK3EGFRALK | |
| SCHEMBL30221455 | 0.92 | ALK (0.70) | JAK3EGFRNUAK1NUAK2ALK | |
| SCHEMBL24900435 | 0.92 | ALK (0.70) | JAK3EGFRNUAK1NUAK2ALK | |
| SCHEMBL17209825 | 0.89 | JAK3 (1.00) | JAK3EGFRNUAK1NUAK2JAK2 | |
| SCHEMBL29504107 | 0.86 | EGFR (1.00) | JAK3EGFRNUAK1NUAK2JAK2 | |
| SCHEMBL31060495 | 0.86 | EGFR (1.00) | JAK3EGFRNUAK1NUAK2JAK2 | |
| SCHEMBL10128042 | 0.86 | EGFR (0.86) | JAK3EGFRNUAK1NUAK2JAK2 | |
| SCHEMBL17209775 | 0.85 | JAK3 (0.85) | JAK3EGFRNUAK1NUAK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118159533-A | Heterocyclic compounds and their use | 艾森医药有限公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023287783-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | ACEA Therapeutics, Inc. (US) | 2023-01-19 | — | — | WO | disclosed |