Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 7/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 7/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.39 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24904266 | 0.83 | KDM4E (0.60) | HDAC1MAPTGAADYRK3DYRK1A | |
| SCHEMBL30494355 | 0.76 | MAPT (0.58) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL23510637 | 0.75 | CLK1 (0.64) | DYRK3DYRK1ADYRK2DYRK1BCSNK2A2 | |
| SCHEMBL30494246 | 0.73 | KDM4E (0.60) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL23499918 | 0.72 | DYRK2 (0.69) | DYRK3DYRK1ADYRK2DYRK1BPIM1 | |
| SCHEMBL28843079 | 0.72 | DYRK2 (0.69) | DYRK3DYRK1ADYRK2DYRK1BPIM1 | |
| SCHEMBL29899894 | 0.72 | DYRK2 (0.69) | DYRK3DYRK1ADYRK2DYRK1BPIM1 | |
| SCHEMBL24904307 | 0.72 | CLK1 (0.49) | DYRK3DYRK1ADYRK2DYRK1BCSNK2A2 | |
| SCHEMBL14464165 | 0.71 | METAP1 (0.49) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL23510481 | 0.71 | KDM4E (0.48) | MAPTGAADYRK3DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025301-A1 | Novel Heterocyclic Derivatives with Cardiomyocyte Proliferation Activity for Treatment of Heart Diseases | TONGJI UNIVERSITY (CN) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025301-A1 | Novel Heterocyclic Derivatives with Cardiomyocyte Proliferation Activity for Treatment of Heart Diseases | TNNI3, TNNT2, MKI67 | HDAC1 70/4885MAPT 4785/4885GAA 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.