Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 8/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 8/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.56 |
| ▸ | PIM1 | P11309 | 5/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 5/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.56 |
| ▸ | CSNK2A3 | Q8NEV1 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | GPR18 | Q14330 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CLK1 | P49759 | 4/20 | 0.36 |
| ▸ | CLK2 | P49760 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30494246 | 0.87 | KDM4E (0.60) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL23510481 | 0.82 | KDM4E (0.48) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL30363453 | 0.81 | MAPT (0.62) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL24904266 | 0.78 | KDM4E (0.60) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL30494162 | 0.76 | MAPT (0.56) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL24904265 | 0.76 | HDAC1 (0.43) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL23510557 | 0.75 | DYRK1A (0.60) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL29899865 | 0.75 | DYRK1A (0.60) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL28842985 | 0.75 | DYRK1A (0.60) | MAPTGAADYRK3DYRK1ADYRK2 | |
| SCHEMBL23970084 | 0.75 | CLK1 (0.60) | MAPTGAADYRK3DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |