Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653890 | 0.77 | HPGD (0.41) | MAOAMAOBTSHRKDM4E | |
| SCHEMBL1072092 | 0.73 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ALMNAACHEMAOA | |
| SCHEMBL2729912 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ALMNAACHEMAOA | |
| SCHEMBL6254274 | 0.70 | LMNA (0.64) | SMN1; SMN2RAB9ALMNAMAOAMAOB | |
| SCHEMBL29448273 | 0.70 | LMNA (0.64) | SMN1; SMN2RAB9ALMNAMAOAMAOB | |
| SCHEMBL8634471 | 0.69 | NPC1 (0.37) | SMN1; SMN2RAB9ALMNAMAOAMAOB | |
| SCHEMBL24325912 | 0.69 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ALMNAACHEMAOA | |
| SCHEMBL10850238 | 0.69 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9ALMNAALDH1A1MAPK1 | |
| SCHEMBL31179793 | 0.69 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ALMNAACHEMAOA | |
| SCHEMBL9445744 | 0.69 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ALMNAACHEMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379053-A1 | PROPHYLACTIC/THERAPEUTIC AGENT FOR CANCER | Takeda Pharmaceutical Company Limited (JP) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010076896-A1 | PROPHYLACTIC/THERAPEUTIC AGENT FOR CANCER | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-07-08 | — | — | WO | disclosed |