Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072092 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL2729912 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL10856992 | 0.71 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL10850238 | 0.71 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL2807200 | 0.71 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL1294648 | 0.71 | SMN1; SMN2 (0.75) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL6254274 | 0.69 | LMNA (0.64) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL2490658 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL29448273 | 0.69 | LMNA (0.64) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL24325912 | 0.68 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5216175-A | Polyoxoheterocyclic tetracylic derivatives | SRI INTERNATIONAL (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0479970-A1 | ANTIMALARIAL ANALOGS OF ARTEMISININ | SRI INTERNATIONAL (US) | 1992-04-15 | — | — | EP | disclosed |
| WO-1991014689-A1 | ANTIMALARIAL ANALOGS OF ARTEMISININ | SRI INTERNATIONAL (US) | 1991-10-03 | — | — | WO | disclosed |