Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 5/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486639 | 0.96 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2490809 | 0.96 | ADORA1 (0.46) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2314978 | 0.95 | NPC1 (0.42) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2318352 | 0.95 | KMT2A (0.48) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2490842 | 0.94 | RORC (0.42) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2489932 | 0.93 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2490672 | 0.91 | ALDH1A1 (0.41) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2487659 | 0.91 | MAPT (0.45) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2490888 | 0.90 | ALDH1A1 (0.39) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL2487593 | 0.90 | ALDH1A1 (0.46) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2559455-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| EP-2548618-A2 | Organic compounds | Novartis AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |