Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156365 | 0.81 | MEN1 (0.42) | MEN1KMT2ANTRK1ALDH1A1POLB | |
| SCHEMBL31483966 | 0.76 | MEN1 (0.41) | MEN1KMT2ANTRK1HTTALDH1A1 | |
| SCHEMBL9409997 | 0.75 | MEN1 (0.45) | MEN1KMT2ANTRK1ALDH1A1POLB | |
| SCHEMBL17156348 | 0.75 | DHFR (0.38) | MEN1KMT2AHTTALDH1A1POLB | |
| SCHEMBL27430987 | 0.72 | TYR (0.35) | MEN1KMT2AHTTALDH1A1POLB | |
| SCHEMBL9298613 | 0.70 | MEN1 (0.44) | MEN1KMT2AALDH1A1POLBTDP1 | |
| SCHEMBL10997608 | 0.70 | MEN1 (0.41) | MEN1KMT2ANTRK1ALDH1A1AHR | |
| SCHEMBL3170487 | 0.69 | MEN1 (0.43) | MEN1KMT2ANTRK1ALDH1A1POLB | |
| SCHEMBL13573529 | 0.68 | KDM4E (0.33) | MEN1KMT2AHTTKDM4E | |
| SCHEMBL3966185 | 0.67 | MEN1 (0.42) | MEN1KMT2ANTRK1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379530-A1 | PYRIMIDINE INDOLE DERIVATIVES FOR TREATING CANCER | AstraZeneca AB (SE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010073034-A1 | PYRIMIDINE INDOLE DERIVATIVES FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | WO | disclosed |