Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4276535 | 0.83 | MEN1 (0.53) | MEN1KMT2ANTRK1POLBALDH1A1 | |
| SCHEMBL17156365 | 0.82 | MEN1 (0.42) | MEN1KMT2ANTRK1POLBALDH1A1 | |
| SCHEMBL9298613 | 0.80 | MEN1 (0.44) | MEN1KMT2APOLBALDH1A1TDP1 | |
| SCHEMBL31483966 | 0.77 | MEN1 (0.41) | MEN1KMT2ANTRK1POLBALDH1A1 | |
| SCHEMBL12639128 | 0.77 | ALDH1A1 (0.43) | MEN1KMT2ANTRK1POLBALDH1A1 | |
| SCHEMBL17506379 | 0.76 | NTRK1 (0.39) | MEN1KMT2ANTRK1ALDH1A1THRB | |
| SCHEMBL17156348 | 0.76 | DHFR (0.38) | MEN1KMT2APOLBALDH1A1TDP1 | |
| SCHEMBL2490824 | 0.75 | MEN1 (0.37) | MEN1KMT2ANTRK1POLBALDH1A1 | |
| SCHEMBL46639 | 0.74 | MEN1 (0.53) | MEN1KMT2ANTRK1POLBALDH1A1 | |
| SCHEMBL9785565 | 0.73 | MAPT (0.38) | MEN1KMT2APOLBTDP1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016022644-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-02-11 | — | — | WO | disclosed |
| EP-0612746-A1 | Pyrimidines and their pharmaceutical acceptable salts and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |
| US-5264435-A | Treatment of neurological diseases | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| US-5147876-A | Nervous system disorders | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-09-15 | — | — | US | disclosed |
| EP-0379806-A2 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |