Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.49 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.49 |
| ▸ | LIPC | P11150 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 2/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 7/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL7105697 | 0.87 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL8477461 | 0.86 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL421582 | 0.86 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL24720949 | 0.86 | JAK2 (0.50) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL8477458 | 0.86 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| Ammonia Solution, Strong SCHEMBL7107044 | 0.84 | PLK1 (0.52) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL2337724 | 0.84 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL6993058 | 0.84 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL16952454 | 0.84 | CES2 (0.46) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL477593 | 0.83 | KDM4E (0.50) | ALDH1A1HPGDKDM4EHSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230014445-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014445-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | ALDH1A1 3272/4885HPGD 2892/4885KDM4E 2710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.