Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 16/20 | 0.68 |
| ▸ | ATP4B | P51164 | 16/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2443681 | 0.98 | ATP4A (0.66) | ATP4AATP4BNPC1CASP3RAB9A | |
| Bromide SCHEMBL2380835 | 0.97 | ATP4A (0.67) | ATP4AATP4BNPC1CASP3RAB9A | |
| SCHEMBL2379298 | 0.90 | ATP4A (0.59) | ATP4AATP4BNPC1RAB9AMEN1 | |
| SCHEMBL2443336 | 0.89 | ATP4A (0.62) | ATP4AATP4BMEN1KMT2A | |
| Bromide SCHEMBL2380483 | 0.88 | ATP4A (0.63) | ATP4AATP4BMEN1KMT2A | |
| SCHEMBL2380102 | 0.88 | ATP4A (0.56) | ATP4AATP4BMEN1KMT2A | |
| SCHEMBL2441512 | 0.87 | ATP4A (0.58) | ATP4AATP4BMEN1KMT2A | |
| SCHEMBL2382887 | 0.87 | ATP4A (0.55) | ATP4AATP4BNPC1CASP3RAB9A | |
| SCHEMBL2380822 | 0.87 | ATP4A (0.55) | ATP4AATP4BNPC1RAB9AMEN1 | |
| Bromide SCHEMBL2379367 | 0.86 | ATP4A (0.59) | ATP4AATP4BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |