SCHEMBL2490905

SCHEMBL2490905

Nc1nc(N)nc(-c2ccccc2Cl)n1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.69
HTR2B P41595 1/20 0.60
PDE4D Q08499 1/20 0.60
HRH4 Q9H3N8 1/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
HSP90AB1 P08238 1/20 0.56
ADORA3 P0DMS8 2/20 0.50
ADORA2A P29274 2/20 0.50
ADORA2B P29275 2/20 0.50
ADORA1 P30542 2/20 0.50
POLB P06746 1/20 0.50
KDM4E B2RXH2 3/20 0.48
ALOX15 P16050 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
ALDH1A1 P00352 4/20 0.46
TSHR P16473 1/20 0.46
LDHA P00338 1/20 0.46
HSD17B10 Q99714 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29808150 1.00 HSP90AA1 (0.69) HSP90AA1HTR2BPDE4DHRH4SMN1; SMN2
SCHEMBL27907211 0.96 HSP90AA1 (0.69) HSP90AA1HTR2BPDE4DHRH4SMN1; SMN2
SCHEMBL4036138 0.87 SMN1; SMN2 (0.65) HSP90AA1HTR2BPDE4DHRH4SMN1; SMN2
SCHEMBL18015441 0.84 LDHA (0.54) HSP90AA1HRH4SMN1; SMN2KDM4EL3MBTL1
SCHEMBL30468191 0.84 SMN1; SMN2 (0.71) HSP90AA1HTR2BPDE4DHRH4SMN1; SMN2
SCHEMBL17046876 0.84 SMN1; SMN2 (0.71) HSP90AA1HTR2BPDE4DHRH4SMN1; SMN2
SCHEMBL4028544 0.83 CYP2D6 (0.54) HSP90AA1HTR2BPDE4DHRH4SMN1; SMN2
SCHEMBL4086070 0.82 HSP90AA1 (1.00) HSP90AA1HTR2BPDE4DHRH4SMN1; SMN2
SCHEMBL10923366 0.79 HRH4 (0.75) HSP90AA1HRH4SMN1; SMN2KDM4EALOX15
SCHEMBL10822462 0.78 HTR2B (0.55) HSP90AA1HTR2BPDE4DHRH4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113461660-B 2,4, 6-trisubstituted-1, 3, 5-s-triazine compound, preparation and application thereof 浙江大学 2022-08-02 CN disclosed
CN-113461660-A 2,4, 6-trisubstituted-1, 3, 5-s-triazine compound, preparation and application thereof 浙江大学 2021-10-01 CN disclosed
US-8330039-B2 Solar cell modules with poly(vinyl butyral) encapsulant comprising unsaturated heterocyclic compound E I DU PONT DE NEMOURS AND COMPANY (US) 2012-12-11 US disclosed
EP-2380208-A1 SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND E. I. du Pont de Nemours and Company (US) 2011-10-26 EP disclosed
WO-2010085664-A1 SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-07-29 WO disclosed
US-20100180947-A1 SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-07-22 US disclosed
EP-0563386-A1 ANTICANCER COMPOSITION AND COMPOUND NIPPON SHINYAKU COMPANY, LIMITED (JP) 1993-10-06 EP disclosed