SCHEMBL10923366

SCHEMBL10923366

Nc1nc(-c2ccccc2Cl)nc(N2CCCCC2)n1

nearest known ligand 0.75

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 7/20 0.75
ALDH1A1 P00352 3/20 0.58
ABCB1 P08183 1/20 0.53
HSP90AA1 P07900 1/20 0.51
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
KMT2A Q03164 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
HTR6 P50406 2/20 0.47
HRH3 Q9Y5N1 1/20 0.47
SIRT5 Q9NXA8 1/20 0.46
KDM4E B2RXH2 1/20 0.44
GLA P06280 1/20 0.44
GAA P10253 1/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
HTT P42858 1/20 0.44
HSD17B10 Q99714 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8412371 0.85 HTR2B (0.63) HRH4ALDH1A1HTR6HRH3SIRT5
SCHEMBL8409850 0.85 HTR2B (0.63) HRH4ALDH1A1HTR6HRH3SIRT5
SCHEMBL8412358 0.83 HTR2B (0.65) HRH4ALDH1A1HTR6HRH3SIRT5
SCHEMBL8410106 0.80 HTR2B (0.65) HRH4ALDH1A1HTR6HRH3SIRT5
SCHEMBL2490905 0.79 HSP90AA1 (0.69) HRH4ALDH1A1HSP90AA1NPC1RAB9A
SCHEMBL29808150 0.79 HSP90AA1 (0.69) HRH4ALDH1A1HSP90AA1NPC1RAB9A
SCHEMBL27907211 0.79 HSP90AA1 (0.69) HRH4ALDH1A1HSP90AA1NPC1RAB9A
SCHEMBL29807976 0.78 HRH4 (0.72) HRH4ALDH1A1NPC1RAB9AKMT2A
SCHEMBL10918295 0.76 HRH4 (0.76) HRH4ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL6984658 0.75 KEAP1 (0.53) HRH4ALDH1A1NPC1SMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0066799-B1 NICOTINIC ACID DERIVATIVES NIPPON SHINYAKU COMPANY, LIMITED (JP) 1986-01-02 EP disclosed
US-4415570-A TREATMENT FOR RHEMATIC DISEASES AND ALLERGIC NEPHRYTIS; UROGENITAL DISORDERS NIPPON SHINYAKU CO. LTD. (JP) 1983-11-15 US disclosed