Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.69 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | JUN | P05412 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27236305 | 1.00 | NFE2L2 (0.69) | NFE2L2CYP11B1CYP11B2ALDH1A1NAMPT | |
| SCHEMBL27820280 | 0.83 | ALDH1A1 (0.55) | NFE2L2CYP11B1CYP11B2ALDH1A1NAMPT | |
| SCHEMBL5572462 | 0.82 | TLR9 (0.64) | NFE2L2ALDH1A1TLR9EGFRKMT2A | |
| SCHEMBL5572469 | 0.82 | TLR9 (0.64) | NFE2L2ALDH1A1TLR9EGFRKMT2A | |
| SCHEMBL29149692 | 0.82 | TLR9 (0.64) | NFE2L2ALDH1A1TLR9EGFRKMT2A | |
| SCHEMBL30195853 | 0.81 | NFE2L2 (0.67) | NFE2L2TLR9EGFR | |
| SCHEMBL27328033 | 0.80 | NFE2L2 (1.00) | NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL4260845 | 0.77 | NFE2L2 (0.58) | NFE2L2CYP11B1CYP11B2ALDH1A1NPC1 | |
| SCHEMBL15758243 | 0.77 | NFE2L2 (0.62) | NFE2L2CYP11B1CYP11B2ALDH1A1NPC1 | |
| SCHEMBL15758245 | 0.77 | NFE2L2 (0.62) | NFE2L2CYP11B1CYP11B2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023003882-A2 | COMPOUNDS HAVING SELECTIVE INACTIVATION ACTIVITY | UNIVERSITY OF NORTH CAROLINA AT WILMINGTON (US) | 2023-01-26 | — | — | WO | disclosed |